Mediford Corporation

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Regenerative Medicine Products Development Support

Contract Services for Regenerative Medicine Products

We provide a wide range of services in the development of regenerative medicine products from consulting to medical writing for diseases that are difficult to treat with conventional methods.
We support each stage of the development process up to submission of application for approval by providing contract services that meet a wide variety of research needs, including toxicity studies (GLP), efficacy and biodistribution studies (reliability standards), and medical writing at research facilities fully accredited by AAALAC.

Efficacy Evaluation

Liver Fibrosis

Hepatitis

  • Nonalcoholic steatohepatitis (NASH) model
  • Carbon tetrachloride-induced hepatitis model

Circulatory Organ/Peripheral Artery Disease

Heart failure

  • Cardiac infarction (ischemia-reperfusion) model

Abdominal aortic aneurysm

  • Calcium chloride-induced abdominal aortic aneurysm model

Peripheral arterial disease

  • Hind limb ischemia model

Central Nervous System

Brain ischemia

  • Transient middle cerebral artery (MCA) occlusion

Depression / Epilepsy

  • Forced swimming test (depression)
  • Tail suspension test (depression)
  • Kainic acid-induced epilepsy

Learning and memory impairment

  • Alzheimer's disease (AD)
  • Scopolamine-induced amnesia
  • Lesions of the nucleus basalis of Meynert

Voiding function

Overactive bladder (OAB: induced by cerebral infarction) model
Lower urinary tract symptoms (LUTS: benign prostatic hyperplasia [BPH])
Spinal cord injury (SUI), stress urinary incontinence

  • Cystometry
  • Uroflowmetry

Interstitial cystitis (IC: hydrochloric acid, cyclophosphamide or acetic acid-induced)

  • Cystometry
  • Uroflowmetry
  • Measurement of spontaneous locomotive activity
  • fMRI

Cancer

Liver cancer

  • Rabbit VX2 cancer transplantation model (only available at mediford)

In vivo antitumor study

  • Splenic liver metastasis model (human colon cancer cell line HT-29)
  • Orthotopic implantation model
    • Orthotopic implantation model
    • Cervical cancer cell line
    • Prostatic cancer cell line
    • Glioblastoma-derived cell line
  • Subcutaneous implantation model
    • SCID, NOD/SCID, and NOG mice are available

Cancer pain

  • Bone metastasis model (rat breast cancer cell line MRMT-1)

Autoimmune Disease

Systemic lupus erythematous (SLE)

  • MRL/lpr mice (spontaneously)
  • NZBWF1 mice (spontaneously)

Rheumatoid arthritis (RA)

  • Type II collagen-induced arthritis model

Multiple Sclerosis (Experimental autoimmune encephalomyelitis: EAE)

  • Relapse-remission type model (SJL mice)
  • Chronic type model (C57BL mice)

Colitis

  • Ulcerative colitis (DSS-induced)
  • Crohn’s disease (TNBS-induced)

Safety Evaluation

Approved for compliance with regenerative medicine GLP

Approved for compliance with regenerative medicine GLP

Safety Assessment Building

Safety Assessment Building

Array Scan

Array Scan
(high-content imaging system)

Thermo Fisher Scientific K.K.
Improved conventional method with high sensitivity and accurate detection Digital soft agar colony formation assay is now available.

Actual working scene using individual ventilation rack used in regenerative medicine related studies

Actual working scene using individual ventilation rack used in regenerative medicine related studies (housing of immunodeficient animals)

Biodistribution study Detection of human mesenchymal stem cells (hMSCs) in rats

Biodistribution study
Detection of human mesenchymal stem cells (hMSCs) in rats

Double staining with anti-human lamine antibody and mitochondrial antibody (Rat lung tissue, arrow: positive cells)

Immunodeficient animal

Species common name Strain
Rat Nude F344/NJcl-rnu/rnu
Mouse Nude CAnN.Cg-Foxn1nu/CrlCrlj, BALB/cAJcl-nu/nu
SCID CB17/lcr-Prkdcscid/CrlCrlj
NOD/SCID NOD.CB17-Prkdcscid/J
NOG NOD.Cg-Prkdcscid Il2rgtm1Sug/ShiJic
NSG NOD.Cg-PrkdcscidIl2rgtm1lWjl/SzJ