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Body weight loss without reduction in food consumption observed in cynomolgus monkeys during non-clinical toxicity studies

• 9:15-11:45, March 24 (Tuesday), 2026
• Presenter: Kazuaki Takahashi
• Cynomolgus monkeys are commonly used in non-clinical toxicity studies because they are more anatomically and physiologically homologous to humans compared to other mammals such as rats. Toxicity studies involving monkeys provide valuable data for drug development regarding the potential effects of drugs on humans.In such studies, weight loss is occasionally observed in monkeys and can be difficult to distinguish from drug-related effects. This study retrospectively analyzed data from control-group monkeys without drug treatment to investigate the incidence of weight loss and its physiological and pathological characteristics. We also investigated potential improvements through enhanced animal welfare. * This is a brief summary of the poster abstract published in The Toxicologist, a publication associated with the Society of Toxicology (SOT) 2026 Annual Meeting.