Mediford Corporation

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Introduction of analytical methods for novel modalities

In recent years, pharmaceutical development is progressing not only with low molecular drugs, but with various sized molecules (middle size to large size) such as nucleic acid pharmaceuticals, antibody pharmaceuticals, and gene therapy agents utilizing various core technologies of drug discovery.

Mediford Corporation offers reliable data for various modalities with our long earned technology and cutting-edge equipment with a focus on low molecular drugs.

Service Details

Determination of Drug Concentrations

Drug modalities Methods Platforms Manufacturer
Nucleic acid medicines and Peptide medicines
<middle-size molecule>		 LC/MS QTRAP 7500 AB SCIEX
Q Exactive Focus Thermo Fisher Scientific
MSI（Mass Spectrometry Imaging） solariX 2XR Bruker
Hybridization-assay and
LBA（Ligand binding assay）		 MESO Quick Plex SQ120 Meso Scale Diagnostics
SMCxPRO Merck
Gyrolab xP workstation Gyros Protein Technologies
VersaMax Molecular Devices
Antibody pharmaceuticals
(ADC, bispecific antibody, etc.)		 MSI solariX 2XR Bruker
LBA MESO Quick Plex SQ120 Meso Scale Diagnostics
SMCxPRO Merck
Gyrolab xP workstation Gyros Protein Technologies
VersaMax Molecular Devices
Gene therapy
(virus vector, plasmid vector, mRNA, etc.)		 qPCR LightCycler 480Ⅱ Roche Diagnostics
Cell based assay VersaMax Molecular Devices
Cell therapy
Regenerative medicine (immune system)
Cancer Immunotherapy (CAR-T, etc.)		 qPCR LightCycler 480Ⅱ Roche Diagnostics
Flow cytometry BD FACSCantoⅡ BD Biosciences
BD FACSLyric BD Biosciences
CyTOF XT Standard BioTools

Immunogenicity assessment (determination of antidrug antibody)

Drug modalities Methods Platforms Manufacturer
Nucleic acid medicine
Peptide medicine
Antibody pharmaceutical
Gene and Cell therapy 		LBA
(including Cell based assay for Neutralization antibody assay)		 MESO Quick Plex SQ120 Meso Scale Diagnostics
SMCxPRO Merck
Gyrolab xP workstation Gyros Protein Technologies
VersaMax Molecular Devices
*1Gene and Cell therapy Flow cytometry
Cell based assay		 BD FACSCantoⅡ BD Biosciences
BD FACSLyric BD Biosciences
CyTOF XT Standard BioTools

※1 Used for analysis of anti-drug antibodies on cell surface

Pharmacometrics analysis

Drug modalities Object of evaluation Methods Platforms Manufacturer
Nucleic acid medicine
Peptide medicine
Antibody pharmaceutical
Gene and Cell therapy 		Spatial distribution Gene and protein expression profiling GeoMx Digital Spatial Profiler
nCounter Analysis System		 NanoString Technologies
Biomarker LBA SMCxPRO Merck
MESO Quick Plex SQ120 Meso Scale Diagnostics
Cellular immunity
(vaccine)		 Flow cytometry BD FACSCantoⅡ BD Biosciences
BD FACSLyric BD Biosciences
CyTOF XT Standard BioTools
Cell based assay Immunospot analyzer Cellular techology Limited
Intermolecular interaction LBA VersaMax Molecular Devices
Gyrolab xP workstation Gyros Protein Technologies
Gene mutation
and Genotyping		 Microarray GeneTitan Multi-channel Instrument Thermo Fisher Scientific
qPCR LightCycler 480Ⅱ Roche Diagnostics
Sequencing Applied Biosystems 3500xLGenetic Analyzer Thermo Fisher Scientific
Cell population Flow cytometry BD FACSCantoⅡ BD Biosciences
BD FACSLyric BD Biosciences
CyTOF XT Standard BioTools