Analytical Instruments

Image Analysis

In Vivo Imaging System

Manufacturer
Revvity (formerly PerkinElmer)
Model
IVIS Lumina III
Instrument
Specifications
  • Peltier-cooled CCD camera (-90°C)
  • 2D luminescence/fluorescence measurement
  • Capable of measuring up to 3 mice simultaneously
  • Equipped with a near-infrared extended light source and newly designed fluorescence filters
Measurement
Applications
  • Image analysis
  • Oncology research
  • Anti-tumor testing
  • Drug efficacy studies
  • Regenerative medicine studies

In Vivo Imaging System (IVIS) is a device used to visually (semi-quantitatively) confirm the in vivo distribution of luminescent or fluorescently labeled cells, antibodies, or other substances administered to animals, by capturing the weak light emitted from the labeled cells or antibodies using the IVIS. This system is widely utilized in cancer research as well as transplantation and regenerative medicine studies.

High-Resolution Ultrasound Imaging System

Manufacturer
FUJIFILM VisualSonics
Model
Vevo F2
Instrument
Specifications
  • Capable of B-mode, M-mode, color Doppler, pulsed wave Doppler, tissue Doppler, strain analysis, 3D image analysis, and 4D image analysis
Measurement
Applications
  • Pharmacology Studies
  • Myocardial infarction models
  • Aortic arch constriction models
  • Pulmonary hypertension models

This is a high-resolution, high-temporal-resolution ultrasound system developed specifically for animal experiments. It enables the measurement of blood flow information and valve motion in small, fast-beating hearts, such as those of mice, which have a diameter of approximately 5 mm and a heart rate exceeding 500 bpm. In addition to cardiac assessments, it can also evaluate major blood vessels, abdominal organs, and other structures.

MALDI FT-ICR Mass Spectrometry Imaging System

Manufacturer
Bruker
Model
solariX 2xR
Measurement
Applications
  • Spatial Analysis in Tissues
  • Evaluation of distribution within tissues through whole tissue analysis (qualitative analysis)
  • Evaluation of tissue localization using high-resolution analysis* (qualitative analysis)
  • (Exploratory) quantitative evaluation through whole tissue analysis*

*: Quantitative analysis is also possible using laser microdissection (LMD)-LC-MS/MS measurement.

This device visualizes the minute localization of multiple target compounds in tissue sections without the need for fluorescent or radioactively labeled compounds. In addition to qualitative analysis (whole tissue analysis and high-resolution analysis), quantitative analysis is also possible.

Micro-CT

Manufacturer
Rigaku
Model
CosmoScan GX II
Measurement
Applications
  • Pharmacology studies
  • Lungs (volume of inflamed area: pneumonia, pulmonary fibrosis, etc.)
  • Bones (bone density, bone volume, BMD value)
  • Fat (body fat area and volume)

This is an X-ray CT device for taking and analyzing images of small animals. By photographing living subjects under anesthesia, it is possible to observe the progression of disease and evaluate drug efficacy over time.

Digital Microscope

Manufacturer
KEYENCE
Model
VHX-8000
Instrument
Specifications
  • Magnification: 0 to 2000x (by changing the lens)
  • Capable of imaging everything from normal animals to cells
  • It is possible to photograph the object directly, not just the fixed stand.
Measurement
Applications

This is a microscope system that photographs and analyzes the "surface" of living organisms and extracted tissues in a realistic and enlarged manner. The focus is automatically maintained, allowing for planar measurements, 3D measurements, volumetric analysis, etc.

Digital Spatial Tissue Profiler

Manufacturer
Bruker Spatial Biology
Model
GeoMx Digital Spatial Profiler
Instrument
Specifications
  • Up to 96 types of proteins and approximately 20,000 types of RNA can be detected.
Measurement
Applications

This is a profiling system that visualizes tumor cells, immune cells, and other components in tissue section slide samples using fluorescent staining. The expression of several tens to approximately 20,000 types of proteins and genes can be analyzed in specific regions of interest.