Analytical Instruments

Drug Concentration / Biomarker Analysis

Mass Spectrometer

Manufacturer
AB SCIEX
Model
QTRAP 7500
Instrument
Specifications
  • Average signal strength 7 times stronger than previous models
  • Six orders of linear dynamic range
  • Ultra-fast polarity switching (5m sec)
Measurement
Applications

This model has the world's highest level of sensitivity and scanning speed. Compared to conventional models, it enables ultra-high sensitivity analysis and simultaneous multi-component analysis. In addition, the control and analysis software has undergone CSV (Computerized System Validation), enabling highly reliable testing. In addition to the QTRAP 7500, Mediford Corporation also has models such as the QTRAP 6500+, QTRAP 5500, Triple Quad 5500, API4000, Shimadzu LCMS-8060, and LCMS-8060NX.

High Resolution Mass Spectrometer

Manufacturer
Thermo Fisher Scientific K.K.
Model
Q EXACTIVE FOCUS
Instrument
Specifications
  • Resolution 70,000@m/z 200
  • m/z range: 50 to 3000
  • Mass accuracy: < 3 ppm(external standard)
Measurement
Applications

This instrument is capable of handling a wide range of analysis applications, from small molecules to medium-sized molecules, covering both qualitative and quantitative analyses. Additionally, the control and analysis software has undergone CSV (Computerized System Validation), enabling highly reliable testing.

Manufacturer
Thermo Fisher Scientific K.K.
Model
Orbitrap IQ-X
Instrument
Specifications
  • Resolution 500,000@m/z 200
  • m/z range: 50 to 2000
  • Mass accuracy: sub 1 ppm(EASY-IC)
Measurement
Applications

This is a high-resolution mass spectrometer capable of multi-stage MSn acquisition. In compound metabolite searches, the two features of this instrument—"Automated comprehensive MS2 acquisition for unknown metabolites (Acquire X)" and "Selective MS3 acquisition (Real-time library search)"—enable the provision of highly accurate data more efficiently and quickly.
Additionally, it supports LC-RAD/MS (analysis using radioactive isotopes).

HPLC (High-Performance Liquid Chromatography)

HPLC (High-Performance Liquid Chromatography)
Manufacturer
Shimadzu Corporation
Model
Nexera X3
Instrument
Specifications
  • Maximum allowable pressure: 130 Mpa
  • Number of samples to process: 288 (96-well plates)
Measurement
Applications

This is a general-purpose semi-micro HPLC capable of ultra-high performance liquid chromatography (UHPLC) analysis. We also have ample experience in leveraging this capability to perform high-speed, high-separation analysis. In addition to the Nexera X3, Mediford Corporation also owns Nexera X2, Prominence UFLC XR, LC-2050, and Waters Alliance HPLC e2695.

ECL (Electrochemiluminescence)

ECL (Electrochemiluminescence)
Manufacturer
Meso Scale Diagnostics, LLC.
Model
MESO QuickPlex SQ 120
Instrument
Specifications
  • Detection limit of 0.05-1 pg/mL in most assays.
  • Dynamic range 10^5 or more
Measurement
Applications

This is a highly sensitive immunoassay instrument capable of measurements across a wide dynamic range. By utilizing electrochemiluminescence (ECL) technology, it enables multiplex measurement of up to 10 items.

Gyrolab System

Manufacturer
Gyros Protein Technologies AB
Model
Gyrolab xP workstation
Instrument
Specifications
  • Measurement time: 1 hour/CD x 5CDs can be measured simultaneously.
  • Fluorescence measurement detection
Measurement
Applications

This is an immunoassay system that uses Bioaffy CD instead of plates and can automate the process from sampling to measurement. In Bioaffy CD, reactions proceed within microchannels, making it possible to measure extremely small sample volumes on the nL scale. It has the characteristic of minimizing the effects of contaminants in the sample matrix.

SMCxPRO System

Manufacturer
Merck Millipore
Model
SMCxPRO System
Instrument
Specifications
  • Low concentration biomarkers can be detected at fg/mL levels
  • Dynamic range 10^4 to 10^5
Measurement
Applications

This is an ELISA system that enables highly sensitive biomarker detection. This device uses Single Molecular Counting (SMC) technology for measurement, and can be used as a transition kit from a sandwich ELISA kit.

Bio-Plex Multiplex System

Manufacturer
Bio-Rad Laboratories
Model
Bio-Plex 200 Full System
Instrument
Specifications
  • Multiplex measurement of up to 100 items possible
  • All bead types, compatible with 96-well plates
Measurement
Applications

This is a multiplex analysis system utilizing Luminex xMAP technology, capable of measuring multiple biomarkers simultaneously with high sensitivity from small sample volumes. Various kits manufactured by Bio-Rad, Merck, and R&D Systems can be used.

Microplate Reader

Manufacturer
Molecular Device Japan
Model
SpectraMax iD3
Instrument
Specifications
  • Absorbance (230-1000 nm), fluorescence, and luminescence measurements
  • Temperature control possible from room temperature to 66℃
  • Compatible with 6 to 384 well plates
Measurement
Applications

Equipped with a xenon flash lamp and ultra-cooled photomultiplier tube (PMT), this instrument achieves the highest sensitivity and a wide dynamic range by reducing background noise. Wavelengths can be selected in 1.0 nm increments to meet a variety of measurement needs. In addition to this instrument, Mediford Corporation also owns VersaMax and SpectraMax ABS from Molecular Device Japan, GloMax Navigator System from Promega, Varioskan LUX from Thermo Fisher Scientific, and EnSight from PerkinElmer, so you can select the model that is best suited to your measurement system.

Multimode Plate Reader

Manufacturer
Revvity
Model
EnSight
Instrument
Specifications
  • Absorbance measurement module
  • Fluorescence intensity measurement module
  • High-sensitivity luminescence measurement module
  • AlphaScreen measurement module
Measurement
Applications

This instrument supports absorbance measurement, fluorescence intensity measurement, high-sensitivity luminescence measurement, AlphaScreen measurement, and AlphaLISA. Compared to conventional plate readers, it offers higher sensitivity for chemiluminescence measurements. In particular, the Alpha technology, which utilizes a bead-based platform, enables highly sensitive detection of targets (such as proteins, phosphorylation, and other modifications) using small sample volumes (> 5 μL).