Analytical Instruments

Genetic Analysis

Droplet Digital PCR System

Manufacturer
Bio-Rad Laboratories
Model
QX200 Droplet Reader
Instrument
Specifications
  • TaqMan probes or EvaGreen assays
  • 96 samples per run, 5-order dynamic range
Measurement
Applications
  • in vivo distribution evaluation (quantitative analysis)
  • Nucleic acid quantification

This is a highly sensitive and high-resolution PCR system that enables the precise determination of the copy number of target gene sequences. It allows for absolute quantification without the need for a calibration curve. The system is particularly suited for the evaluation of in vivo distribution of regenerative medicine products and gene therapy drugs.

Real Time PCR System

Manufacturer
Roche Diagnostics K.K.
Model
LightCycler 480Ⅱ
Instrument
Specifications
  • Single or multi-color measurements possible
  • Compatible with a 96- or 384-well plate
Measurement
Applications
  • Genetic Analysis
  • Gene quantification (gene detection, absolute quantification, relative quantification, gene expression analysis)
  • Gene Mutation Analysis (genotyping using hydrolysis probes)
  • Multiple plate analysis (96- or 384-*well plate) *384-well plates are only compatible with Light Cycler 480 II
  • Pharmacology Studies
  • Pharmacokinetic Studies

The LightCycler 480II is a proven, high-performance real-time PCR instrument. A versatile plate-based instrument for single or multi-color applications. In addition to the LightCycler 480II, Mediford Corporation also owns the Thermo Fisher Scientific QuantStudio 7Pro and 7500 Fast Dx Real-Time PCR instruments.

2100 Bioanalyzer Electrophoresis System

2100 Bioanalyzer Electrophoresis System
Manufacturer
Agilent Technologies, Inc.
Model
G2939B
Instrument
Specifications
  • Electrophoresis system with a microfluidic chip
Measurement
Applications
  • In vivo distribution evaluation (quantitative analysis)
  • Nucleic acid quantification

This is an electrophoresis system utilizing Lab-on-a-Chip technology. By performing electrophoretic analysis of DNA, RNA, and proteins, it enables the acquisition of digital data such as concentration, size, and quality assessment tailored to specific purposes.

Gene Titan MC System

Manufacturer
Thermo Fisher Scientific K.K.
Model
GeneTitan Multi-Channel Instrument System
Instrument
Specifications
  • An automated microarray processing system that integrates hybridization, washing, and image processing into one unit
  • Process up to 96 samples simultaneously for gene expression analysis and up to 384 samples simultaneously for genotyping
Measurement
Applications
  • Genetic Analysis
  • Genetic Expression Analysis (whole transcriptome analysis, gene expression profiling, genome-wide miRNA and truncated non-coding RNA analysis)
  • Genotyping (genome-wide association analysis, targeted genotyping, population genetic surveys, biobank research)
  • Pharmacogenomics

This is an automatic microarray processing device exclusively for array plates. Automation reduces inter-operation bias and delivers high-quality data. Multiple array plate formats enable gene expression analysis and genotyping. It can be used for a wide range of applications, including whole transcriptome analysis, gene expression profiling, genome-wide association studies (GWAS), and pharmacogenomics.

Next Generation Sequencer

Manufacturer
Illumina, Inc
Model
NextSeq 2000
Instrument
Specifications
  • Proven benchtop sequencer using Sequence by Synthesis (SBS) technology
Measurement
Applications
  • Genetic Analysis
  • Small-scale whole genome sequencing
  • Total RNA-Seq
  • mRNA-Seq
  • 16S RNA sequencing

This is a sequencing system that utilizes patterned flow cell technology to support a wide range of sequencing applications. Depending on the cartridge and flow cell combination, output ranges from 40 to 330 Gb and data from 0.4 to 1.1 billion reads per run. Using UDI allows for measurement of up to 384 samples.

GeneChip System

Manufacturer
Thermo Fisher Scientific K.K.
Model
GCS3000Dx v.2 System
Instrument
Specifications
  • Up to 48 cartridge arrays can be measured at once
  • High resolution scanning possible
Measurement
Applications

The instrument is capable of scanning at high resolutions ranging from 0.51 to 2.5 μm depending on the array type. Up to 48 arrays can be measured. Applied Biosystem's proprietary Flying Objective lens technology features optimal image uniformity and collection efficiency across the entire scan area. We are an authorized service provider of Affymetrix.

DNA Microarray Scanner

Manufacturer
Agilent Technologies
Model
G2600D
Instrument
Specifications
  • Five orders of magnitude wide dynamic range
  • Multi-array format support
Measurement
Applications
  • Genetic Analysis
  • Gene Expression Analysis (biomarker discovery, toxicogenomics research)
  • miRNA-Analysis (Analysis of the relationship between disease and miRNA)

This device uses Sure Print technology to measure high-quality slide-type arrays with high sensitivity. The dynamic range is five orders of magnitude. Support for multi-array formats allows for low-cost measurements. Catalog arrays and customization are also available.

nCounter System

Manufacturer
Bruker Spatial Biology
Model
nCounter Analysis System
Instrument
Specifications
  • Fluorescent molecular barcode probes to digitally detect target sequence patterns.
Measurement
Applications
  • Genetic Analysis
  • RNA expression analysis (trace RNA, lncRNA, fusion gene, miRNA)
  • DNA analysis (SNV, copy number)
  • Protein expression analysis

This is a system that enables digital counting of target molecules without the need for PCR amplification, making it ideal for crude samples derived from FFPE. The automated post-hybridization purification and cartridge preparation functions minimize human bias and ensure consistent data quality. In addition to catalog and custom panels, it also supports multiplex analysis of 96 samples x 96 genes and protein expression analysis. Up to 800 genes can be measured simultaneously, enabling low-cost measurement.

Capillary Sequencer

Manufacturer
Thermo Fisher Scientific K.K.
Model
3500xL
Instrument
Specifications
  • 24-capillary system supports high-throughput measurements
Measurement
Applications

This is a device that determines the base sequence of DNA using the Sanger sequencing method. Two 96-well plates can be analyzed simultaneously in one measurement, allowing up to 192 samples to be measured. It also supports DNA fragment analysis. There is no need to prepare consumables yourself, and the automatic consumables management function enables stable data acquisition.