Efficacy Evaluation
Liver Fibrosis
Hepatitis
- Nonalcoholic steatohepatitis (NASH) model
- Carbon tetrachloride-induced hepatitis model
Circulatory Organ/Peripheral Artery Disease
Heart failure
- Cardiac infarction (ischemia-reperfusion) model
Abdominal aortic aneurysm
- Calcium chloride-induced abdominal aortic aneurysm model
Peripheral arterial disease
- Hind limb ischemia model
Central Nervous System
Brain ischemia
- Transient middle cerebral artery (MCA) occlusion
Depression / Epilepsy
- Forced swimming test (depression)
- Tail suspension test (depression)
- Kainic acid-induced epilepsy
Learning and memory impairment
- Alzheimer's disease (AD)
- Scopolamine-induced amnesia
- Lesions of the nucleus basalis of Meynert
Voiding Function
Overactive bladder (OAB: induced by cerebral infarction) model
Lower urinary tract symptoms (LUTS: benign prostatic hyperplasia [BPH])
Spinal cord injury (SUI), stress urinary incontinence
- Cystometry
- Uroflowmetry
Interstitial cystitis (IC: hydrochloric acid, cyclophosphamide or acetic acid-induced)
- Cystometry
- Uroflowmetry
- Measurement of spontaneous locomotive activity
- fMRI
Cancer
Liver cancer
- Rabbit VX2 cancer transplantation model (only available at mediford)
In vivo antitumor study
- Splenic liver metastasis model (human colon cancer cell line HT-29)
- Orthotopic implantation model
- Orthotopic implantation model
- Cervical cancer cell line
- Prostatic cancer cell line
- Glioblastoma-derived cell line
- Subcutaneous implantation model
- SCID, NOD/SCID, and NOG mice are available
Cancer pain
- Bone metastasis model (rat breast cancer cell line MRMT-1)
Autoimmune Disease
Systemic lupus erythematous (SLE)
- MRL/lpr mice (spontaneously)
- NZBWF1 mice (spontaneously)
Rheumatoid arthritis (RA)
- Type II collagen-induced arthritis model
Multiple Sclerosis (Experimental autoimmune encephalomyelitis: EAE)
- Relapse-remission type model (SJL mice)
- Chronic type model (C57BL mice)
Colitis
- Ulcerative colitis (DSS-induced)
- Crohn’s disease (TNBS-induced)
